Publications
SARS-CoV-2 Infection Activates Inflammatory Macrophages in Vascular Immune Organoids
Wang Chau, C., To, A., Au-Yeung, R.K.H., Tang, K., Xiang, Y., Ruan, D., Zhang, L., Wong, H., Zhang, S., Au, M.T., Chung, S., Song, E., Choi, D.-H., Liu, P., Yuan, S., Wen, C., and Sugimura, R. (2024). bioRxiv. doi: 10.1101/2024.03.20.585837
Single-Cell Mitochondrial Variant Enrichment Resolved Clonal Tracking and Spatial Architecture in Human Embryonic Hematopoiesis
Xue, Y., Chao, Y., Lin, X., Huang, Y., Ho, J.W.K., and Sugimura, R. (2023). bioRxiv. doi: 10.1101/2023.09.18.558215
Organoid-Based Single-Cell Spatiotemporal Gene Expression Landscape of Human Embryonic Development and Hematopoiesis
Chao, Y., Xiang, Y., Xiao, J., Zheng, W., Ebrahimkhani, M.R., Yang, C., Wu, A.R., Liu, P., Huang, Y., and Sugimura, R. (2023). Signal Transduction and Targeted Therapy, 8, 230. doi: 10.1038/s41392-023-01455-y
Integrating Spatial and Single-Cell Transcriptomics Data Using Deep Generative Models With SpatialScope
Wan, X., Xiao, J., Tam, S.S.T., Cai, M., Sugimura, R., Wang, Y., Wan, X., Lin, Z., Wu, A.R., and Yang, C. (2023). Nature Communications, 14, 7848. doi: 10.1038/s41467-023-43629-w
Generation of Natural Killer Cells from Human Expanded Potential Stem Cells
Ching, P. Y., Wang, C., Hang, S., Liu, P., and Sugimura, R. (2023). Journal of Visualized Experiments, 191, e64608. doi:10.3791/64608
PD-L1 Regulates Inflammatory Programs of Macrophages From Human Pluripotent Stem Cells
Cao, H., Xiang, Y., Zhang, S., Chao, Y., Guo, J., Aurich, T., Ho, J.W.K., Huang, Y., Liu, P., and Sugimura, R. (2023). Life Science Alliance, 7 (2) e202302461. doi: 10.26508/lsa.202302461
COVID-19: Locked in a Pro-Inflammatory State (PDF)
Wang Chau, C. and Sugimura, R. (2022) eLife, 11:e80699. doi: 10.7554/eLife.80699
ZFP281-BRCA2 Prevents R-loop Accumulation During DNA Replication (PDF)
Wang, Y., Ma, B., Liu, X., Gao, G., Che, Z., Fan, M., Meng, S., Zhao, X., Sugimura, R., Cao, H., Zhou, Z., Xie, J., Lin, C., and Luo, Z. (2022). Nature Communications, 13, 3493. doi: 10.1038/s41467-022-31211-9
Single-Cell Approaches to Deconvolute the Development of HSCs
Xiang, Y. and Sugimura, R. (2021). Cells, 10(11), 2876.
Recent Advances and Future Prospects in Immune Checkpoint (ICI)-Based Combination Therapy for Advanced HCC
Dong, Y, Wong, J.S.L., Sugimura, R, Lam, K.-O., Li, B, Kwok, G.G.W., Leung, R, Chiu, J.W.Y., Cheung, T.T., Yau, T. (2021). Cancers. 13(8):1949.
Biomimetic Aorta-Gonad-Mesonephros on-a-Chip to Study Human Developmental Hematopoiesis
Sugimura, R.*, Ohta, R*., Mori, C., Li, A., Mano, T., Sano, E., Kosugi, K., Nakahata, T., Niwa, A., Saito, M., Torisawa, Y. (2020). Biomedical Microdevices.
* Equal contribution
Angiocrine Factors From HUVECs Amplify Erythroid Cells
Sugimura, R.*, Ohta, R*., Mori, C., Sano, E., Sugiyama, T., Nagasawa, T., Niwa, A., Torisawa, Y., Saito, M. (2019). Biorxiv (preprint).
* Equal contribution
Hemogenic Endothelium Differentiation From Human Pluripotent Stem Cells in a Feeder- and Xeno-Free Defined Condition
Ohta, R*., Sugimura, R.*, Niwa, A., Saito, M. (2019). Journal of Visualized Experiments.
* Equal contribution
Hematopoietic Stem and Progenitor Cells from Human Pluripotent Stem Cells
Sugimura, R., Jha, D., Han, A., Soria-Valles, C., da Rocha, E., Lu, Y., Goettel, J., Serrao, E., Rowe, R., Malleshaiah, M., Wong, I., Sousa, P., Zhu, T., Ditadi, A., Keller, G., Engelman, A., Snapper, S., Doulatov, S., Daley, G. (2017). Nature, 545, 432-438.
Maternal-Imprinting at H19-Igf2 Locus Maintains Adult Hematopoietic Stem Cell Quiescence
Venkatraman, A., He, X.C., Thorvaldsen, J., Sugimura, R., Perry, P., Tao, F., Zhao, M., Christenson, M., Sanchez, R., Yu, J., Peng, L., Haug, J., Paulson, A., Li, H., Zhong, X., Clemens, T., Bartolomei, M., Li, L. (2013). Nature, 500, 345-349.
Noncanonical Wnt Signaling Maintains Hematopoietic Stem Cells in the Niche
Sugimura, R., He, X.C., Venkatraman, A., Arai, F., Box, A., Semerad, C., Haug, J., Peng, L., Zhong, X., Suda, T., Li, L. (2012). Cell, 150, 351-365.
Cooperation Between Both Wnt/{beta}-catenin and PTEN/PI3K/Akt Signaling Promotes Primitive Hematopoietic Stem Cell Self-Renewal and Expansion
Perry, J.M., He, X.C., Sugimura, R., Grindley, J.C., Haug, J.S., Ding, S., and Li, L. (2011). Genes & Development, 25, 1928-1942.